Somatic Mutations of lats2 Cause Peripheral Nerve Sheath Tumors in Zebrafish
نویسندگان
چکیده
منابع مشابه
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors.
TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly 50% of all tumors exhibiting a loss-of-function mutation. To further elucidate the genetic pathways involving TP53 and cancer, we have exploited the zebrafish, a powerful vertebrate model system that is amenable to whole-genome forward-genetic analysis and synthetic-lethal screens. Zebrafish lines harboring m...
متن کاملMalignant Peripheral Nerve Sheath Tumors (MPNST)
INTRODUCTION Malignant peripheral nerve sheath tumors (MPNSTs) are sarcomas which originate from peripheral nerves or from cells associated with the nerve sheath, such as Schwann cells, perineural cells, or fibroblasts. Because MPNSTs can arise from multiple cell types, the overall appearance can vary greatly from one case to the next. This can make diagnosis and classification somewhat difficu...
متن کاملHybrid peripheral nerve sheath tumors: A review.
Hybrid peripheral nerve sheath tumors (HPNST) are relatively recently described tumors. With ongoing research, a considerable amount of important findings have been made, much of which has substantial clinical implications. However, a comprehensive review of the whole topic has not been published in the literature so far. In the presented manuscript, the various hybrid tumors are discussed sepa...
متن کاملRetrospective analysis of oral peripheral nerve sheath tumors in Brazilians.
Traumatic neuroma, neurofibroma, neurilemmoma, palisaded encapsulated neuroma and malignant peripheral nerve sheath tumor (MPNST) are peripheral nerve sheath tumors and present neural origin. The goal of this study was to describe the epidemiological data of oral peripheral nerve sheath tumors in a sample of the Brazilian population. Biopsies requested from the Oral Pathology Service, School of...
متن کاملHighly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers.
Aneuploidy is a hallmark of human cancers, but most mouse cancer models lack the extensive aneuploidy seen in many human tumors. The zebrafish is becoming an increasingly popular model for studying cancer. Here we report that malignant peripheral nerve sheath tumors (MPNSTs) that arise in zebrafish as a result of mutations in either ribosomal protein (rp) genes or in p53 are highly aneuploid. K...
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ژورنال
عنوان ژورنال: Cells
سال: 2019
ISSN: 2073-4409
DOI: 10.3390/cells8090972